The gene has four transcript variants encoding two. Gpatch4 gene genecards gptc4 protein gptc4 antibody. Evolutionarily conserved gpatch domaincontaining protein evolutionarily conserved signaling intermediate in toll pathway evolutionarily distinct and globally endangered. G proteincoupled receptor gpcr signaling in osteoblasts obs is an important regulator of bone formation. Complete information for sugp1 gene proteincoding, surp and g patch domain containing 1, including. The hgnc resources will be at risk daily between 3am and 9am gmt for approximately 1 hour. G patch domain containing 11 gpbp1l1 gcrich promoter binding protein 1like 1. Functional enrichment analysis of g4binding proteins can be used to elucidate biological roles of genomic g4s and possible side effects of g4based therapeutics. G patch domaincontaining protein 2 ipr026291 interpro entry. Semiquantitative reverse transcriptionpolymerase chain.
The protein has been found to interact with several other proteins, including two from a splicing pathway. Promotes the utilization of a cryptic splice site created by the beta110 mutation in the hbb gene. The g patch is a glycinerich domain discovered by sequence alignment, involved in protein protein and protein nucleic acid interaction. Complete information for gpatch4 gene protein coding, gpatch domain containing 4, including. Protein annotations for g patch domaincontaining protein. A mutation in the serinerich region of the protein is thought to be associated with hyperuricemia pmid. Gpkow g patch domain and kow motifscontaining protein ensg00000068394 51 16% multiple yes 10 supplemental table 1 dix, m. Aug 31, 2011 posttranscriptional processing of premrna takes place in several steps and requires involvement of a number of rnabinding proteins. The gpatch is a glycinerich domain discovered by sequence alignment, involved in proteinprotein and proteinnucleic acid interaction. Human gpatch2 shares approximately 80% and 71% amino acid identity with its. Proteins containing gpatch domains, such as gpatch2, are implicated in rna processing summary by lin et al. Antig patch domain and kow motifscontaining protein antibody produced in rabbit, antig patch domaincontaining protein 5 antibody produced in rabbit, antiprotein mos2 homolog antibody produced in rabbit, antiprotein t54 antibody produced in rabbit. Gprotein coupled receptor 14 definition of gprotein. Value of the data these data describe the use of human protein microarrays to identify binding partners of g4 dna structures.
We can not exclude the possibility that gpkow also binds dna in addition to rna since other g patch domain containing proteins have been shown to be involved in dna repair and telomere maintenance 46, 42, 47 as well as rnaprocessing 48, 49. Its consensus sequence consists of 6 highly conserved glycines according to the following sequence. Activated rna polymerase ii transcriptional coactivator p15. Gpatch2 g patch domaincontaining protein 2 homo sapiens. G patch domaincontaining protein 8 is a protein that in humans is encoded by the gpatch8 gene hyperuricemia. Gpatch2 gpatch domain containing 2 is a protein coding gene. Zentella, rodolfo, zhang, zhonglin, park, mehea, thomas, stephen g, endo, akira, murase, kohji, fleet. Total percent persistent previously explicit ipi number. Omim entry 616836 gpatch domaincontaining protein 2. G patch domain and kow motifs containing protein, gpkow. G patch domain containing protein 8 is a protein that in humans is encoded by the gpatch8 gene. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites.
Complete information for gpatch1 gene protein coding, g patch domain containing 1, including. Data set on g4 dna interactions with human proteins. Zgpat, zinc finger ccchtype and gpatch domain containing. Fbox protein 21 fibroblast growth factor receptor like 1 fmr1 autosomal homolog 2 forkhead box j3 g3bp stress granule assembly factor 2 glucosidase ii alpha subunit glycine nmethyltransferase g patch domain containing 8 h2a clustered histone 20 h2a clustered histone 4 h2b clustered histone 8 hdgf like 2 heat shock protein 90 beta family member 1. Gpatch1 g patch domaincontaining protein 1 homo sapiens. Protein annotations for g patch domaincontaining protein 4.
The cultured podocyte proteomic database cpodoprot contains proteins revealed by mass spectrometry analysis of cultured mouse podocytes reference. Diseases associated with sugp1 include acquired immunodeficiency syndrome. These mice showed a dramatic agedependent increase in trabecular bone of femurs. Ozoneinduced dysregulation of neuroendocrine axes requires. Assessing the osteoblast transcriptome in a model of. Gpatch2 g patch domain containing 2 is a protein coding gene.
Gpatch domain containing 2, a gene highly expressed in. Fbox protein 21 fibroblast growth factor receptor like 1 fmr1 autosomal homolog 2 forkhead box j3 g3bp stress granule assembly factor 2 glucosidase ii alpha subunit glycine nmethyltransferase gpatch domain containing 8 h2a clustered histone 20 h2a clustered histone 4 h2b clustered histone 8 hdgf like 2 heat shock protein 90 beta family member 1. Rna helicases from the deahrha family are present in all the processes of rna metabolism. Q5vyk7, q5vyk8, q86ye7 this subsection of the entry information section shows the date of integration of the entry into uniprotkb, the date of the last sequence update and the date of the last annotation modification last modified. Gpatch domain and kow motifscontaining protein, gpkow. G patch domain containing 11 gpbp1l1 gcrich promoter binding protein 1like 1 gpc4 glypican 4 gpld1. Tested in western blot wb, immunofluorescence if and immunocytochemistry icc applications.
Proteins containing g patch domains, such as gpatch2, are implicated in rna processing summary by lin et al. Gene ontology go annotations related to this gene include nucleic acid binding. We previously described a mouse model expressing rs1, an engineered constitutively active g scoupled gpcr, under the control of the 2. The gene has four transcript variants encoding two functional protein isoforms and is expressed in most human tissues. We can not exclude the possibility that gpkow also binds dna in addition to rna since other gpatch domain containing proteins have been shown to be involved in dna repair and telomere maintenance 46,42,47 as well as rnaprocessing 48,49. Clinical trial of genedisease association and geneenvironment interaction. Posttranscriptional processing of premrna takes place in several steps and requires involvement of a number of rnabinding proteins.
G patch domain containing 2 gpatc2, a human gene that is highly expressed in the testes, was implicated as a novel cancertestis antigen. Gpatch2 gene genecards gptc2 protein gptc2 antibody. G patch domain and ankyrin repeatcontaining protein 1, g patch domain and ankyrin repeatscontaining protein 1, g patch domain containing 10, hlabassociated transcript 4, ankyrin repeat domaincontaining protein 59, g patch domaincontaining protein 10, protein bat4, protein g5, hlab associated transcript 4. The protein encoded by this gene contains an rnaprocessing domain, a zinc finger domain, a lysinerich region and a serinerich. Gpatch2l g patch domaincontaining protein 2like homo.
One domain of gpkow figure figure1b1b is consistent with a gpatch domain of approximately 48 amino acids that has been identified in 775 proteins pfam database. The function of two helicases from this family, prp2 and prp43, is regulated by protein partners containing a g patch domain. The resulting frameshift leads to sickle cell anemia. Complete information for gpatch1 gene protein coding, gpatch domain containing 1, including. G patch domain and ankyrin repeat containing protein 1, g patch domain and ankyrin repeats containing protein 1, g patch domain containing 10, hlabassociated transcript 4, ankyrin repeat domain containing protein 59, g patch domain containing protein 10, protein bat4, protein g5, hlab associated transcript 4. The catalytic c subunit of protein kinase a pka is a serinethreonine kinase, which regulates numerous cellular processes including premrna splicing. Pdf gpatch domain and kow motifscontaining protein, gpkow. Aug 31, 2011 we can not exclude the possibility that gpkow also binds dna in addition to rna since other g patch domain containing proteins have been shown to be involved in dna repair and telomere maintenance 46,42,47 as well as rnaprocessing 48,49. Gpatch domain containing 2 gpatc2, a human gene that is highly expressed in the testes, was implicated as a novel cancertestis antigen. Heart, liver, gut, ovary, testis, brain, placenta, frontal cortex, liver, spinal cord, ovary, urinary bladder,testis, heart, lung,adrenal gland, kidney, gallbladder.
Zinc finger ccchtype with g patch domaincontaining protein. Omim entry 614396 gpatch domaincontaining protein 8. Ipi00294962 sh3kbp1 isoform 1 of sh3 domaincontaining kinasebinding protein 1 ensg00000147010 43 19. Cultured podocytes either differentiated or undifferentiated were lysed in lysis buffer containing 8m urea and were subjected to intip scx fractionation. Go annotations related to this gene include rna binding. Involvement of gpatch domain containing 2 overexpression in. The present study investigated gpatc2 expression in a number of human cell lines and rat tissues, and its potential biological function in 293t cells. Gpatch4 g patch domaincontaining protein 4 homo sapiens. The deduced 528amino acid gpatch2 protein has a highly conserved cterminal gpatch domain.
The gpatch domain is an approximately 48 amino acid domain, which is found in a single copy in several rnaassociated proteins and in type d retroviral polyproteins. Diseases associated with gpatch2 include lymphogranuloma venereum and granuloma inguinale. How premrna processing is regulated is in large enigmatic. Bhlhb2, class e basic helixloophelix protein 40 basic helixloophelix domain containing, class b, 2. Ccdc75, g patch domain containing protein 11coiledcoil domain containing 75. It is widespread among eukaryotes but is absent in archaea and bacteria. Involvement of gpatch domain containing 2 overexpression in breast carcinogenesis article in cancer science 1008. The function of two helicases from this family, prp2 and prp43, is regulated by protein partners containing a gpatch domain. Zinc finger ccchtype with g patch domain containing protein. Pdf gpatch domain and kow motifscontaining protein. Gpatch11 is a protein that in humans is encoded by the g patch domain containing protein 11 gene. Fbox protein 40 fcer1g fc fragment of ige, high affinity i, receptor for. Ccdc75, g patch domaincontaining protein 11coiledcoil domain containing 75. The g patch domain consists of a conserved pattern of glycines and is thought to possess rnabinding affinity.
Gpatch1 gene genecards gptc1 protein gptc1 antibody. Sugp1 surp and g patch domain containing 1 is a protein coding gene. Involvement of gpatch domain containing 2 overexpression. We can not exclude the possibility that gpkow also binds dna in addition to rna since other gpatch domain containing proteins have been shown to be involved in dna repair and telomere maintenance 46, 42, 47 as well as rnaprocessing 48, 49. We demonstrate that gpkow, which contains one gpatch domain and. Hect and rld domain containing e3 ubiquitin protein ligase 4 1. Browse our g patch domain and ankyrin repeats 1 proteins. Csa1g560720 gene cucumber chinese long v2 cucurbit. Bmp10, bone morphogenetic protein 10, bone morphogenetic protein10. The protein encoded by this gene contains an rnaprocessing domain, a zinc finger domain, a lysinerich region and a serinerich region. Ccdc4, ben domaincontaining protein 4coiledcoil domain containing 4. Doublestranded rnabinding protein staufen homolog 2. Help pages, faqs, uniprotkb manual, documents, news archive and biocuration projects.
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